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KMID : 0382619980180020149
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Hanyang Journal of Medicine
1998 Volume.18 No. 2 p.149 ~ p.156
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An Immunohistochemical Study of p53 and mdm-2 Expression in Cutaneous T-cell Lymphomas
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Ro Young-Suck
Park Chan-Kum
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Abstract
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P53 gene mutation appears to play an important role in the development of systemic lymphoma, and may be associated with tumor progression. However, its role in cutaneous lymphoma is currently unknown and only very limited series have focused on the role of p53 in cutaneous T-cell lymphoma. As dysfunction of p53 has also been suggested to occur after interaction with mdm-2 cellular oncogene, we have performed immunohistochemical analysis to investigate the patterns of p53 and mdm-2 expression in 12 cases of cutaneous T-cell lymphoma. Six cases were positive for p53, of which five were found to be high grade lymphomas, and eight cases were positive for mdm-2, of which six were found to be high grade lymphomas. All cases showing positive staining of p53 were of stage Ⅲ or Ⅳ. In six cases of primary cutaneous T-cell lymphomas, only one case was positive for p53. There was no consistent relationship between the expression of p53 and mdm-2, and the abnormal nuclear expression of p53 and mdm-2 did not seem to correlate with the presence of Epstein-Barr virus infection.
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KEYWORD
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p53, mdm-2, EBV, Cutaneous T-cell lymphoma,
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